Maria Juanita HyperFood® Dietary Supplement
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Maria Juanita HyperFood® Dietary Supplement contains 110 mg of Veri-te™ Resveratrol, an ideal ingredient for use in ‘Beauty from Within’ products.

“In the anti-aging market where proven effectiveness really counts, resveratrol offers a powerful and scientifically-backed ingredient that can help rejuvenate and energize skin.”

 

Skin health, a matter of protection

Pollution as well as unhealthy habits (poor nutrition, sun-bathing and smoking) can contribute to the development of oxidative stress and damage our skin. This can cause age spots, wrinkles, and even chronic inflammation, giving skin a prematurely aged look.[i] Resveratrol’s antioxidant and anti-inflammatory properties can contribute to the preservation of healthier and younger looking skin.[ii]

 

Oral intake of resveratrol blend shows anti-aging effects in skin

Antioxidant properties of resveratrol and its effect on skin health has been the topic of many discussions.

A placebo controlled, double-blind study[iii] showed that resveratrol:

° Significantly decreased systemic oxidative stress and increased plasmatic antioxidant capacity, and skin antioxidant power

° Improved skin moisturization and elasticity

° Diminished skin roughness and depth of wrinkles

° Significantly decreased intensity of age spots

50 individuals between 35 and 65 years, 60 days, blend containing 8 mg resveratrol and other ingredients

 

Research indicates resveratrol may promote skin whitening

Resveratrol has several intra-cellular targets that mediate its biological effects.[iv] Among these targets, resveratrol binds and inhibits the activity of tyrosinase, a key enzyme involved in melanogenesis.[v] A study[vi] in an animal model analyzed the effects of topical resveratrol in UVB-induced pigmentation and

indicated resveratrol:

° Inhibits melanin synthesis by inhibiting tyrosinase and other enzymes

° Significantly decreases pigmentation in skin

° Could be used to treat skin disorders such as hyperpigmentation and skin photo-aging e.g. age spots

 

Resveratrol helps to reduce acne

As with other polyphenols, resveratrol has some mild antimicrobial properties. Unlike other polyphenols,

resveratrol has been shown to be particularly active against several acne-forming strains.[vii],[viii] A single-blind,

vehicle-controlled, pilot study[ix] using a resveratrol-containing hydrogel for the treatment of acne vulgaris

showed that resveratrol:

° Produced a 53.75% mean reduction in the Global Acne Grading System (GAGS) score

° Reduced the average area of microcomedones by 66.7% (little plugs, first sign of acne)

20 individuals affected by acne, 60 days, ~0.01% w/v – only right side of the face

 

Study suggests the possible impact of resveratrol on psoriasis

Resveratrol’s anti-inflammatory properties was recently the subject of a review paper.[x] A recent animal

study[xi] that analyzed the protective effects of resveratrol against induced psoriasis-like skin inflammation.

The study showed that resveratrol:

° Induced the expression of genes associated with retinoic acid stimulation and reduced

expression of certain pro-inflammatory cytokine genes that are central in developing psoriasis

° Reduced skinfold thickening

° Improved erythema (red skin) and scaling scores

 

References

[i] Poljšak B and Dahmane R. Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. 2012, 135206 (2012).

[ii] Farris, P. et al. Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 12, 1389-1394. (2013).

[iii] Buonocore, D. et al. Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 5, 159–165 (2012).

[iv] Britton, R. G., Kovoor, C. and Brown, K. Direct molecular targets of resveratrol : identifying key interactions to unlock complex mechanisms. Ann N Y Acad Sci. 1348, 124–133 (2015).

[v] Bernard, P. and Berthon, J. Resveratrol : an original mechanism on tyrosinase inhibition. Int J Cosmet Sci. 22, 219–226 (2000).

[vi] Lee, T. H. et al. Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pig mentation in Guinea Pig Skin. Biomol Ther (Seoul). 22, 35-40 (2014).

[vii] Coenye, T. et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 19, 409–412 (2012).

[viii] Kim, S. O. Y. et al. Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the  inactivation of the PI3-K / Akt pathway. Int J Mol Med. 35, 1042–1050 (2015).

[ix] Fabbrocini, G. and Study, P. Resveratrol-Containing Gel for the Treatment of Acne Vulgaris Resveratrol-Containing Gel for the Treatment of Acne Vulgaris. Am J Clin Dermatol. 12,133-141 (2011).

[x] Poulsen, M. M. et al. Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes. Biochimica et Biophysica Acta 1852, 1124–1136 (2015).

[xi] Kjær, T. et al. Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. PLoS One. 10, 1–18 (2015).

 

*Courtesy Evolva, http://www.veriteresveratrol.com/

 

Refrences

 

[1] Poljšak B and Dahmane R. Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. 2012, 135206 (2012).

[1] Farris, P. et al. Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 12, 1389-1394. (2013).

[1] Buonocore, D. et al. Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 5, 159–165 (2012).

[1] Britton, R. G., Kovoor, C. and Brown, K. Direct molecular targets of resveratrol : identifying key interactions to unlock complex mechanisms. Ann N Y Acad Sci. 1348, 124–133 (2015).

[1] Bernard, P. and Berthon, J. Resveratrol : an original mechanism on tyrosinase inhibition. Int J Cosmet Sci. 22, 219–226 (2000).

[1] Lee, T. H. et al. Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pig mentation in Guinea Pig Skin. Biomol Ther (Seoul). 22, 35-40 (2014).

[1] Coenye, T. et al. Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine. 19, 409–412 (2012).

[1] Kim, S. O. Y. et al. Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the  inactivation of the PI3-K / Akt pathway. Int J Mol Med. 35, 1042–1050 (2015).

[1] Fabbrocini, G. and Study, P. Resveratrol-Containing Gel for the Treatment of Acne Vulgaris Resveratrol-Containing Gel for the Treatment of Acne Vulgaris. Am J Clin Dermatol. 12,133-141 (2011).

[1] Poulsen, M. M. et al. Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes. Biochimica et Biophysica Acta 1852, 1124–1136 (2015).

[1] Kjær, T. et al. Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. PLoS One. 10, 1–18 (2015).

 

*Courtesy Evolva, http://www.veriteresveratrol.com/